Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligas
Human,Rat
WB,IHC-P,IHC-F,ICC/IF,IF
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.